Potable water reuse started as pioneering efforts in Southern California and Windhoek, Namibia 50 years ago. This practice has seen tremendous growth over the last 15 years in various regions of the globe adopting the latest treatment approaches, performance control strategies, or water quality monitoring approaches. However, since reclaimed water typically poses greater technical and institutional challenges than traditional water supplies, regulators and the general public are concerned about the safety of using reclaimed water for potable reuse purposes.   Dr. Jörg Drewes, Chair Professor of Urban Water Systems Engineering at the Technical University of Munich (TUM), Germany, provides an overview of various potable reuse treatment approaches following the design concept of multiple barriers and the latest risk assessment strategies applied to these schemes. A critical evaluation of the water reuse systems as well as treatment combinations will be given considering actual performance results from full-scale installations. The knowledge presented can assist utility managers, design engineers, regulators, operators and researchers in their work. This Master Lecture was recorded during the IWA World Water Congress & Exhibition, Tokyo 2018